Saturday, September 06, 2008

What makes nicotine so addictive?

There may be a very good reason why coffee and cigarettes often seem to go hand in hand. 

A Kansas State University psychology professor's research suggests that nicotine's power may be in how it enhances other experiences. For a smoker who enjoys drinking coffee, the nicotine may make a cup of joe even better. 

And that may explain why smoking is so hard to quit. 
I wonder if this will offer an answer to some of my questions about nicotine. 

I'm not sure. Some of this just doesn't sit well with me:
"The big picture is trying to figure out why people smoke," Palmatier said. "There are a lot of health risks, and the majority of smokers already know what they are. They want to quit but can't. It's not because nicotine is a potent drug; it doesn't induce significant amounts of pleasure or euphoria. Yet, it's just as difficult if not more difficult to quit than other drugs."

At K-State, Palmatier studies rats that are allowed to self-administer nicotine by pushing a lever. The main source of light in their testing environment shuts off when the rats earn a dose of nicotine. After about a minute, the light comes back on to signal that more nicotine is available.

By manipulating this signal, Palmatier and his colleagues found that the rats weren't really that interested in nicotine by itself.

"We figured out that what the rats really liked was turning the light off," Palmatier said. "They still self-administered the nicotine, but they took more of the drug when it was associated with a reinforcing light."

Palmatier and colleagues published a paper on their research in the August issue of Neuropsychopharmacology.

Palmatier has begun looking at how rats respond to sweet tastes after having nicotine. He said preliminary results show that nicotine has comparable effects on sweet tastes. That is, rats respond more for sugar-water solutions after getting nicotine.

"The taste aspect is really important because we can actually figure out how nicotine is increasing the subjects' behavior," Palmatier said. "If it makes a reward more pleasurable, then it may increase the palatability of a sweet taste."
If so, it would have to be soley on  a neurobiological level because on an oral taste level, because nothing tastes better with a cigarette.

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